Perturb tumor cells or their spatial TME context to predict the response of marker genes.

(1) Choose a perturbation type; (2) Configure parameters; (3) Monitor progress in real time.

Basic Configuration

ISP Type

Model ID

Marker Set

Perturbation Parameters

Genes

0 genes selected

Single gene = single mode; multiple = combination mode

Cell Type

ISP Fold >1 = Expand, 0~1 = Delete, 0 = Delete all

Fix Cell Types

No Yes

0 cell types selected

Select cell types to fix (others will adjust).

Simulation Settings

Number of Cells

ISP Virtual Perturbation: input perturbation types and output marker gene response

Perturbation Plan

ISP Type Target Rank — Perturb tumor cells or their spatial TME context, and predict the response of tumor cell marker genes. Use this to identify key regulators within tumor cells.

Model TMEformer — A TME-aware spatial transformer model that integrates each tumor cell's intrinsic transcriptional profile with spatially neighboring microenvironmental cells through a TME context encoding module.

Perturbation Select parameters above to see your perturbation plan.

Simulation Perturb for random 100 tumor cells among all available samples.